It has a bacteriostatic activity that the 3-D modeling recognized as positive, with the virus being negative, and thus engaging the Glycoprotein Spike (S). In order to facilitate said testing, the CDCC sent Dr. laRive a 3-D modeling sequence for COVID-19 [see figure 2 – Glycoprotein Spike (S)]. In applying TMRS’s product specifications to the 3-D rendering, Dr. laRive noticed, 1) that Glycoprotein Spike (S) was dismantled in the 3-D modeling, potentially providing a control factor for the uncontrolled force-flow coughing and sneezing, associated with the COVID-19’s transmission.
The Glycoprotein Spike (S) is a multifunctional molecular machine that mediates coronavirus entry into host cells. It first binds to a receptor on the host cell surface, through its S1 subunit (recombinant S1 subunit of human SARS coronavirus (isolate: WH20).
The spike comprises 665 aminoacids and has a predicted molecular mass of 74.4 kDa, and then fuses to viral and host membranes, through its S2 Subunit. (The S2 Subunit of QX-type Infectious Bronchitis Coronavirus Spike Protein Is an essential determinant of COVID-19.) Two domains in S1, stemming from different Coronaviruses, are recognized a variety of host receptors, leading to viral attachments.
The spike protein exists in two structurally distinct conformations: pre-fusion and post-fusion. The transition from pre-fusion to post-fusion conformation of the spike protein must be triggered, leading to membrane fusion. The term, R0 (pronounced, “R-naught”) associates a number, indicating how many people that one person infected with the virus is likely to infect.
For example, if R0 is 3, then on average, every confirmed case of COVID-19 will lead to three other people infected with the virus. Although this metric seems simple to conceptualize, the margin for computational error is high, making it is difficult to calculate and tricky to interpret.